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KMID : 0829320130160020069
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Korean Journal of Clinical Microbiology
2013 Volume.16 No. 2 p.69 ~ p.74
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Association between Apolipoprotein E Genotype andTreatment Response in Chronic Hepatitis C
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Kim Yu-Kyung
Lee Kyung-Min
Lee Won-Kil
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Abstract
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Background: Hepatitis C virus (HCV) causes a chronic infection, resulting in progressive liver damage. Recent studies have described the protective effect of the apolipoprotein E (ApoE) genotype on liver damage in cases of HCV infection. Their findings were explained by the influence of the ApoE genotype on HCV pathology, which seems to be integrally linked to the process of HCV uptake into hepatocytes. We investigated whether specific ApoE genotypeswere associated with the different clinical aspects of HCV infection in patients with chronic HCV.
Methods: From the whole blood of 196 chronic HCVhepatitis patients, the ApoE genotypes were determined by an allele-specific polymerase chain reaction. Several markers, including liver enzymes, platelet counts and HCV viral loads, as well as the radiologic findings, were investigated. In order to estimate the treatment outcome, the sustained virologic response (SVR), early virologic response (EVR) and end-of-treatment response (ETR) were determined according to the HCV viral loads.
Results: Based on genotyping, 15.8% (n=31) of the patients had the ApoE E4 allele (E2/E4, E3/E4,E4/E4), while 84.2% (n=165) were missing the ApoEE4 allele (E2/E2, E2/E3, E3/E3). Several clinical resultsof the E4-positive group, including liver enzymes,albumin, platelet counts, HCV viral loads and hepatic coarseness were not significantly different from those of E4-negative group. There were no differences in the SVR, EVR and ETR between patients with the ApoE E4 allele and those without theApoE E4 allele.
Conclusion: There was no significant effect of theApoE genotype on the clinical aspects of HCV infectionand the anti-viral response, including SVR, EVRand ETR, in chronic HCV hepatitis patients.
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KEYWORD
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Apolipoprotein E genotype, Hepatitis C virus, Polymorphism
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